Blar i forfatter "Page, Christian Magnus"

Viser treff 1-3 av 3

    • Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome 

      Bucher-Johannessen, Cecilie; Page, Christian Magnus; Haugen, Trine B.; Wojewodzic, Marcin; Fosså, Sophie Dorothea; Grotmol, Tom; Haugnes, Hege Sagstuen; Rounge, Trine Ballestad (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)
      <i>Background</i> - Cisplatin-based chemotherapy (CBCT) is part of standard treatment of several cancers. In testicular cancer (TC) survivors, an increased risk of developing metabolic syndrome (MetS) is observed. In this epigenome-wide association study, we investigated if CBCT relates to epigenetic changes (DNA methylation) and if epigenetic changes render individuals susceptible for developing ...

    • Global test for high-dimensional mediation: Testing groups of potential mediators 

      Djordjilovic, Vera; Page, Christian Magnus; Gran, Jon Michael; Nøst, Therese Haugdahl; Sandanger, Torkjel M; Veierød, Marit Bragelien; Thoresen, Magne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-09)
      We address the problem of testing whether a possibly high‐dimensional vector may act as a mediator between some exposure variable and the outcome of interest. We propose a global test for mediation, which combines a global test with the intersection‐union principle. We discuss theoretical properties of our approach and conduct simulation studies that demonstrate that it performs equally well or ...

    • Pre-diagnostic DNA methylation in blood leucocytes in cutaneous melanoma; a nested case–control study within the Norwegian Women and Cancer cohort 

      Page, Christian Magnus; Nøst, Therese Haugdahl; Djordjilović, Vera; Thoresen, Magne; Frigessi, Arnoldo; Sandanger, Torkjel M; Veierød, Marit Bragelien (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-20)
      The prognosis of cutaneous melanoma depends on early detection, and good biomarkers for melanoma risk may provide a valuable tool to detect melanoma development at a pre-clinical stage. By studying the epigenetic profile in pre-diagnostic blood samples of melanoma cases and cancer free controls, we aimed to identify DNA methylation sites conferring melanoma risk. DNA methylation was measured at ...